1/53
Obesidad y síndrome metabólico en la infancia / M Barrio; M López Capapé; E Colino; C Mustieles; M Alonso.-- pp. 65-74.-- En: Endocrinol Nutr.-- 52, 2 (2005)
OBESIDAD   SINDROME METABOLICO   SINDROME X METABOLICO   RESISTENCIA A LA INSULINA   DIABETES MELLITUS TIPO II   ENFERMEDADES CARDIOVASCULARES
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-0063
Tipo de Material:
Separata

    La prevalencia de obesidad se ha incrementado en las últimas 2 décadas de forma alarmante y ha alcanzado valores de pandemia. Se estima que más de 1000 millones de personas en el mundo son obesos. En Estados Unidos, el 65% de la población adulta y el 15% de los niños presentan sobrepeso u obesidad, sin objetivarse una tendencia descendente de esas cifras en los estudios epidemiológicos publicados en el año 2004.
    En la actualidad, la obesidad en la población pediátrica es el trastorno nutricional más frecuente. La incidencia de sobrepeso en la infancia se ha triplicado en los últimos 30 años. Deckelbaum et.al., refieren que unos 22 millones de niños menores de 5 años tienen sobrepeso en el mundo, con una valoración reciente realizada en Estados Unidos se muestra que el 16% de los niños entre 6 y 12 años presenta obesidad, datos muy próximos a los de la población infantil norteamericana....Continua.

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2/53
Adipose tissue and the insulin resistance syndrome / KN Frayn.-- pp. 375-80.-- En: Proceedings of the Nutrition Society.-- 60, 3 (2001)
TEJIDO ADIPOSO   RESISTENCIA A LA INSULINA   SINDROME X METABOLICO   OBESIDAD   TRIGLICERIDOS
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-0069
Tipo de Material:
Separata

    Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance....Continua.

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3/53
Metabolic syndrome a new world-wide definition. A Consensus Statement from the International Diabetes Federation / KG Alberti; P Zimmet; J Shaw.-- pp. 469-80.-- En: Diabetic Medicine.-- 23, 5 (2006)
SINDROME METABOLICO   SINDROME X METABOLICO   TEJIDO ADIPOSO   HIPERTENSION   OBESIDAD   RESISTENCIA A LA INSULINA   ADULTO
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-0127
Tipo de Material:
Separata

    AIMS: To establish a unified working diagnostic tool for the metabolic syndrome (MetS) that is convenient to use in clinical practice and that can be used world-wide so that data from different countries can be compared. An additional aim was to highlight areas where more research into the MetS is needed. PARTICIPANTS: The International Diabetes Federation (IDF) convened a workshop held 12-14 May 2004 in London, UK. The 21 participants included experts in the fields of diabetes, public health, epidemiology, lipidology, genetics, metabolism, nutrition and cardiology. There were participants from each of the five continents as well as from the World Health Organization (WHO) and the National Cholesterol Education Program-Third Adult Treatment Panel (ATP III). The workshop was sponsored by an educational grant from AstraZeneca Pharmaceuticals. CONSENSUS PROCESS: The consensus statement emerged following detailed discussions at the IDF workshop. After the workshop, a writing group produced a consensus statement which was reviewed and approved by all participants...continua.

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4/53
Esteatosis hepática en niños obesos / B González Pérez; R Salas Flores.-- pp. 74-82.-- En: Revista de Endocrinología y Nutrición.-- 16, 2 (2008)
ESTEATOHEPATITIS NO ALCOHOLICA   HEPATOPATIAS   ESTRES OXIDATIVO   RESISTENCIA A LA INSULINA   ASPARTATO AMINOTRANSFERASAS
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-0869
Tipo de Material:
Separata

    Desde su descripción inicial en 1980 la enfermedad de hígado grado no alcohólico (NAFLD) ha llegado a ser la forma más común de enfermedad del hígado en niños y adolescentes. EL aumento dramático de la obesidad observada en las últimas décadas, se ha acompañado con el incremento en la prevalencia de las complicaciones de la obesidad, incluyendo NAFLD e incluye un amplio espectro de daño al hígado, desde una simple esteatosis, esteatohepatitis, varios grados de fibrosis e incluso cirrosis. En la práctica clínica, el diagnóstico se puede sospechar después de encontrar elevación crónica de aminotransferasas séricas y la presencia de imágenes ultrasonográficas de grasa en hígada (incremento de la ecogenicidad). Continua.

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5/53
Inadequate vitamin d status: does it contribut to the disorders comprising syndrome X ? / BJ Boucher.-- pp.315-327.-- En: British Journal of Nutrition.-- 79 (1998)
VITAMINA D   DEFICIENCIA DE VITAMINA D   SINDROME   RESISTENCIA A LA INSULINA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-2380
Tipo de Material:
Separata




6/53
Glucose fatty acid interactions in health and disease / JD McGarry.-- pp.500S-504S.-- En: American Journal of Clinical Nutrition.-- 67 (1998)
GLUCOSA   SALUD   ENFERMEDAD   LIPIDOS   DIABETES MELLITUS   HIPERINSULINISMO   RESISTENCIA A LA INSULINA   OBESIDAD   CARNITINA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-2436
Tipo de Material:
Separata




7/53
Insulin resistance and non insulin dependent diabetes mellitus: celular and molecular mechanisms / JM Olefsky; JJ Nolan.-- pp.980S-986S.-- En: American Journal of Clinical Nutrition.-- 61 (1995)
DIABETES MELLITUS TIPO II   GLUCOSA   RESISTENCIA A LA INSULINA   RECEPTORES DE INSULINA   HIPERGLICEMIA   FOSFORILACION
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-3148
Tipo de Material:
Separata




8/53
Pediatric endocrinology / F, edited Lifshitz .-- 5th ed. .--New York : Informa Healthcare, 2007.-- 787 p.
ENDOCRINOLOGIA   DIABETES   OBESIDAD   RESISTENCIA A LA INSULINA   HIPOGLICEMIA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: 618.924.L722.2007
Tipo de Material:
Monografias

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9/53
Implicaciones clínicas de la obesidad, su relación con el síndrome de resistencia a la insulina y la importancia de la evaluación de la grasa visceral / A Pietrobelli; MC Velázquez Alva.-- pp. 293-5.-- En: Nutrición Clínica.-- 5, 4 (2002)
OBESIDAD   RESISTENCIA A LA INSULINA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-5887
Tipo de Material:
Separata




10/53
Role of dietary factors: micronutrients / RA Anderson.-- p.S10-S11.-- En: Nutrition Reviews.-- 58, (3 Pt 2) (2000)
ACIDO ASCORBICO   INSULINA   RESISTENCIA A LA INSULINA   MICRONUTRIENTES   NECESIDADES NUTRICIONALES   OLIGOELEMENTOS   VITAMINA E
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-4760
Tipo de Material:
Separata

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11/53
Type 2 diabetes in children and youth / FR Kaufman.-- p. 659-76.-- En: Endocrinology and Metabolism Clinics of North America.-- 34, 3 (2005)
DIABETES MELLITUS TIPO II   RESISTENCIA A LA INSULINA   SINDROME X METABOLICO   NIÑO   ADOLESCENTE
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-4913
Tipo de Material:
Separata

    The number of children and youth diagnosed with type 2 diabetes has increased dramatically over the last decade. Much still needs to be learned about why this epidemic is occurring presently with regard to other environmental factors that might promote insulin resistance and beta-cell failure. The TODAY trial will help to determine the best treatment strategies to improve glycemia, reduce complications, and ameliorate insulin resistance and beta-cell failure. As type 2 diabetes emerges as a worldwide public health problem, improved care for affected youth must be coupled with a focus on prevention.

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12/53
Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism / SA Amiel; S Caprio; RS Sherwin; G Plewe; MW Haymond; WV Tamborlane.-- pp.277-282.-- En: The Journal of Clinical Endocrinology and Metabolism.-- 72, 2 (1991)
ACIDO 3-HIDROXIBUTIRICO   ADOLESCENCIA   AMINOACIDOS DE CADENA RAMIFICADA   GLUCOSA DE LA SANGRE   NIÑO   ACIDOS GRASOS NO ESTERIFICADOS   TECNICA DE CLAMPEO DE LA GLUCOSA   HUMANO   HIDROXIBUTIRATOS   INSULINA   RESISTENCIA A LA INSULINA   PUBERTAD
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-5092
Tipo de Material:
Separata

    To examine mechanisms underlying the development of insulin resistance during normal puberty, sequential 8 and 40 mU/m2.min euglycemic insulin clamp and hyperglycemic clamp studies were performed in 14 healthy prepubertal and 19 pubertal children. Both groups had comparable rates of glucose turnover and plasma levels of branched chain amino acids and FFA at baseline. The low as well as the high insulin dose stimulated peripheral glucose uptake much more effectively in prepubertal children (P less than 0.05). In contrast, suppression of hepatic glucose production (60% at low dose in both groups, pNS) and lowering of substrates in response to insulin was not affected by puberty at either dose. During the hyperglycemic clamp pubertal children showed enhanced insulin responses and in turn a sharper fall in amino acids (P less than 0.05 vs. prepubertals). Our data suggest that insulin resistance during puberty is restricted to peripheral glucose metabolism. Selective insulin resistance leading to compensatory hyperinsulinemia may serve to amplify insulin's effect on amino acid metabolism, thereby facilitating protein anabolism during this period of rapid growth.

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13/53
Fructose, weight gain, and the insulin resistance syndrome / SS Elliott; NL Keim; JS Stern; K Teff; PJ Havel.-- pp. 911-922.-- En: American Journal of Clinical Nutrition.-- 76, 5 (2002)
Notas de Contenido:
Material no impreso
RESISTENCIA A LA INSULINA   TRIGLICERIDOS   CARBOHIDRATOS EN LA DIETA   FRUCTOSA   HUMANO   HIPERLIPIDEMIA   HIPERTENSION   SINDROME X METABOLICO   AUMENTO DE PESO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    This review explores whether fructose consumption might be a contributing factor to the development of obesity and the accompanying metabolic abnormalities observed in the insulin resistance syndrome. The per capita disappearance data for fructose from the combined consumption of sucrose and high-fructose corn syrup have increased by 26%, from 64 g/d in 1970 to 81 g/d in 1997. Both plasma insulin and leptin act in the central nervous system in the long-term regulation of energy homeostasis. Because fructose does not stimulate insulin secretion from pancreatic ß cells, the consumption of foods and beverages containing fructose produces smaller postprandial insulin excursions than does consumption of glucose-containing carbohydrate. Because leptin production is regulated by insulin responses to meals, fructose consumption also reduces circulating leptin concentrations. The combined effects of lowered circulating leptin and insulin in individuals who consume diets that are high in dietary fructose could therefore increase the likelihood of weight gain and its associated metabolic sequelae. In addition, fructose, compared with glucose, is preferentially metabolized to lipid in the liver. Fructose consumption induces insulin resistance, impaired glucose tolerance, hyperinsulinemia, hypertriacylglycerolemia, and hypertension in animal models. The data in humans are less clear. Although there are existing data on the metabolic and endocrine effects of dietary fructose that suggest that increased consumption of fructose may be detrimental in terms of body weight and adiposity and the metabolic indexes associated with the insulin resistance syndrome, much more research is needed to fully understand the metabolic effect of dietary fructose in humans.

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14/53
Treatment of obesity: need to focus on high risk abdominally obese patients / JP Després; I Lemieux; D Prud'homme.-- pp. 716-720.-- En: British Medical Journal.-- 322, 7288 (2001)
Notas de Contenido:
Material no impreso
TEJIDO ADIPOSO   ADULTO   ARTERIOSCLEROSIS   CONSTITUCION CORPORAL   INDICE DE MASA CORPORAL   CORONARIOPATIA   DIABETES MELLITUS TIPO II   HIPERTRIGLICERIDEMIA   RESISTENCIA A LA INSULINA   OBESIDAD   FACTORES DE RIESGO   VISCERAS
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

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15/53
What is an optimal diet? Relationship of macronutrient intake to obesity, glucose tolerance, lipoprotein cholesterol levels and the metabolic syndrome in the Whitehall II study / EJ Brunner; H Wunsch; MG Marmot.-- pp. 45-53.-- En: International Journal of Obesity and Related Metabolic Disorders.-- 25, 1 (2001)
Notas de Contenido:
Material no impreso
ADULTO   CONSTITUCION CORPORAL   INDICE DE MASA CORPORAL   COLESTEROL   ESTUDIOS DE COHORTES   ESTUDIOS TRANSVERSALES   CARBOHIDRATOS EN LA DIETA   GRASAS EN LA DIETA   PROTEINAS EN LA DIETA   ACIDOS GRASOS NO SATURADOS   FEMENINO   TEST DE TOLERANCIA A LA GLUCOSA   HUMANO   RESISTENCIA A LA INSULINA   LIPOPROTEINAS   MASCULINO   ENFERMEDADES METABOLICAS   MEDIA EDAD   OBESIDAD   CUESTIONARIO   FACTORES DE RIESGO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    OBJECTIVE: Saturated fats have adverse effects on health. To investigate which is more beneficial for energy replacement, we compare the effects of polyunsaturated fatty acid and carbohydrate intake on obesity and metabolic variables (fasting triglycerides, HDL-cholesterol, LDL-cholesterol and 2 h glucose). Further, because the optimum diet may differ according to glucose tolerance, we examine the same associations in glucose tolerant and intolerant groups. Finally, we test the effect of macronutrient intake on the presence or absence of the metabolic syndrome. DESIGN: Cross-sectional analysis. SUBJECTS: A total of 4497 men and 1865 women aged 39--62 in the Whitehall II study. RESULTS: In men, higher intakes of both polyunsaturated fats and carbohydrates were linked to lower waist-hip ratio, triglycerides and LDL-cholesterol. Higher carbohydrate intake alone was linked to decreased body mass index (for 10 g higher carbohydrate intake, -0.12 kg/m(2), P<0.0001) and lower HDL-cholesterol (-0.01 mmol/l, P<0.01). In normoglycaemic men, higher carbohydrate intakes were associated with higher 2 h insulin and glucose levels (0.25 pmol/l, P<0.05 and 0.01 mmol/l, P=0.001, respectively). Dietary effects among women were similar, the exception being a positive association of polyunsaturated fat intake with body mass index and waist--hip ratio (0.47 kg/m(2), P<0.05 and 0.006, P<0.05, respectively). Dietary components, with the exceptions of cholesterol and protein in men, were unrelated to prevalence of the metabolic syndrome, and adjustment for differences in macronutrient intake did not account for the strong inverse association between socioeconomic position and the metabolic syndrome. CONCLUSION: Our observational data provide evidence that both polyunsaturated fatty acids and carbohydrates offer small metabolic benefits with few adverse effects compared with saturated fats.

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16/53
Maternal carbohydrate metabolism and its relationship to fetal growth and body composition / PM Catalano; NM Drago; SB Amini.-- pp. 1464-1470.-- En: American Journal of Obstetrics and Gynecology.-- 172, 5 (1995)
TEJIDO ADIPOSO   ADULTO   ANTROPOMETRIA   PESO AL NACER   COMPOSICION CORPORAL   CARBOHIDRATOS   DESARROLLO FETAL   EDAD GESTACIONAL   GLUCOSA   RECIEN NACIDO   INSULINA   RESISTENCIA A LA INSULINA   HIGADO   PESO DE LOS ORGANOS   PADRES   PLACENTA   EMBARAZO   ESTUDIOS PROSPECTIVOS   ANALISIS DE REGRESION   FACTORES SEXUALES
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-5461
Tipo de Material:
Separata

    OBJECTIVE: Our purpose was to correlate maternal carbohydrate metabolism and parental morphometric measurements with neonatal birth weight, body composition, and placental weight. STUDY DESIGN: Sixteen singleton (six control and 10 abnormal glucose tolerance) infants had placental weight, birth weight, and estimates of body composition performed within 24 hours of birth. Independent variables considered were (1) maternal and paternal demographic and morphometric measures, (2) neonatal sex and gestational age, and (3) estimates of maternal carbohydrate metabolism, including basal hepatic glucose production, insulin response, and insulin sensitivity. All metabolic measurements were performed before conception and in early (12 to 14 weeks) and late (34 to 36 weeks) gestation. Best-fit stepwise regression analysis was used to relate the independent variables with placental weight, neonatal birth weight, fat-free mass, and fat mass. RESULTS: Insulin sensitivity in late gestation had the strongest correlation with placental weight (R2 = 0.28), neonatal birth weight (R2 = 0.28), and fat-free mass (R2 = 0.33). In contrast, insulin sensitivity before conception had the best correlation with neonatal fat mass (R2 = 0.15). Including all significant independent variables in the model improved the correlations for placental weight (R2 = 0.58), birth weight (R2 = 0.48), fat-free mass (R2 = 0.53), and fat mass (R2 = 0.46). CONCLUSION: Maternal insulin sensitivity had stronger correlations with fetoplacental growth in comparison with maternal demographic or morphometric factors.




17/53
Funciones endocrinas de la célula adiposa / M González Hito; RB Bastidas; MB Ruiz; S Godínez; A Panduro.-- pp. 140-146.-- En: Revista de Endocrinología y Nutrición.-- 10, 3 (2002)
Notas de Contenido:
Material no impreso
TEJIDO ADIPOSO   SECRECIONES   RESISTENCIA A LA INSULINA   OBESIDAD   DIABETES MELLITUS TIPO II
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    El tejido adiposo se encarga de guardar la mayor reserva de energía en el organismo. El adipocito posee las enzimas que se requieren en la lipólisis y en la lipogénesis, procesos metabólicos finamente modulados por acción de hormonas, citocinas y otras moléculas implicadas en la regulación del metabolismo energético. Las células claras del tejido adiposo son muy activas en la síntesis y secreción de señales que actúan de manera endocrina, paracrina y autocrina. Algunas de estas señales tienen efectos locales en el metabolismo del tejido adiposo, en tanto que otras tienen acción sistémica e integran una red de señales que participan en la regulación de funciones en diversos tipos de células localizadas en órganos distantes, tales como hipotálamo, hígado, páncreas, músculo esquelético, etc. Los adipocitos son células de secreción endocrina, recientemente, se ha generado bastante evidencia acerca de las diversas citocinas, hormonas, factores de crecimiento y otros componentes proteicos que se expresan y secretan en el tejido adiposo del humano. En esta revisión presentamos factores que se conoce son expresados y secretados en el tejido adiposo, el papel que tienen en la fisiopatología de la resistencia a la insulina, la obesidad y la diabetes mellitus tipo 2.

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18/53
Insulin resistant syndromes in children / S Caprio; SA Amiel; P Merkel; WV Tamborlane.-- p. 112-4.-- En: Hormone Research.-- 39, Suppl 3 (1993)
Notas de Contenido:
Material no impreso
NIÑO   HUMANO   RESISTENCIA A LA INSULINA   PUBERTAD   SINDROME   SINDROME DE TURNER   BETATALASEMIA
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Puberty is normally associated with a decline in tissue sensitivity to insulin. However, normal glucose homoeostasis is maintained by compensatory increases in glucose-stimulated insulin secretion. Here we describe studies performed in healthy children which have determined the site of insulin resistance (hepatic vs. peripheral) and whether this resistance extends to other substrates such as amino acid and free fatty acid metabolism. The changes in insulin action and secretion that are normally seen during puberty lead us to question the role of insulin resistance in other childhood conditions that are complicated by the later development of type I or type II diabetes, namely thalassaemia major and Turner's syndrome. These studies showed that in patients with thalassaemia and Turner's syndrome, insulin resistance and increased insulin secretion are very early metabolic defects that appear before the development of diabetes.

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19/53
Syndrome X / E Ferrannini.-- p. 107-11.-- En: Hormone Research.-- 39, Suppl 3 (1993)
Notas de Contenido:
Material no impreso
ENFERMEDADES CARDIOVASCULARES   DIABETES   RESISTENCIA A LA INSULINA   HIPERINSULINEMIA   INTOLERANCIA A LA GLUCOSA
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Using cross-sectional and longitudinal analysis of data from the San Antonio Heart Study, syndrome X (primary insulin resistance syndrome) has been redefined in terms of hyperinsulinaemia combined with changes in glucose tolerance, lipid pattern, blood pressure and body fat distribution. Syndrome X is itself an atherogenic cardiovascular risk factor, which interacts with enviromental and genetic factors to lead to the aventual development of the endpoint of cardiovascular disease.

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20/53
Insulin resistance syndrome in children / S Ten; N Maclaren.-- pp. 2526-39.-- En: The Journal of Clinical Endocrinology and Metabolism.-- 89, 6 (2004)
Notas de Contenido:
Material no impreso
RESISTENCIA A LA INSULINA   NIÑO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    The insulin resistance syndrome (syndrome X, metabolic syndrome) has become the major health problem of our times. Associated obesity, dyslipidemia, atherosclerosis, hypertension, and type 2 diabetes conspire to shorten life spans, while hyperandrogenism with polycystic ovarian syndrome affect the quality of life and fertility of increasing numbers of women. Whereas a growing number of single genetic diseases affecting satiety or energy metabolism have been found to produce the clinical phenotype, strong familial occurrences, especially in racially prone groups such as those from the Indian subcontinent, or individuals of African, Hispanic, and American Indian descents, together with emerging genetic findings, are revealing the polygenetic nature of the syndrome. However, the strong lifestyle factors of excessive carbohydrate and fat consumption and lack of exercise are important keys to the phenotypic expression of the syndrome. The natural history includes small for gestational age birth weight, excessive weight gains during childhood, premature pubarche, an allergic diathesis, acanthosis nigricans, striae compounded by gynecomastia, hypertriglyceridemia, hepatic steatosis, premature atherosclerosis, hypertension, polycystic ovarian syndrome, and focal glomerulonephritis appearing increasingly through adolescence into adulthood. Type 2 diabetes, which develops because of an inherent and/or an acquired failure of an insulin compensatory response, is increasingly seen from early puberty onward, as is atheromatous disease leading to coronary heart disease and stroke. A predisposition to certain cancers and Alzheimer’s disease is also now recognized. The looming tragedy from growing numbers of individuals affected by obesity/insulin resistance syndrome requires urgent public health approaches directed at their early identification and intervention during childhood. Such measures include educating the public on the topic, limiting the consumption of sucrose-containing drinks and foods with high carbohydrate and fat contents, and promoting exercise programs in our nation’s homes and schools.

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21/53
Obesity and insulin resistance / BB Kahn; JS Flier.-- pp. 473-81.-- En: The Journal of Clinical Investigation.-- 106, 4 (2000)
Notas de Contenido:
Material no impreso
RESISTENCIA A LA INSULINA   OBESIDAD   TEJIDO ADIPOSO   DIABETES MELLITUS TIPO II   HOMEOSTASIS   GLUCOSA   RATONES   MODELOS BIOLOGICOS
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

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22/53
Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults / MA Pereira; DR Jacobs; JJ Pins; SK Raatz; MD Gross; JL Slavin; et.al..-- pp. 848-55.-- En: American Journal of Clinical Nutrition.-- 75, 5 (2002)
Notas de Contenido:
Material no impreso
ADULTO   PESO CORPORAL   CEREALES   ESTUDIOS CRUZADOS   AYUNO   TECNICA DE CLAMPEO DE LA GLUCOSA   HOMEOSTASIS   HIPERINSULINISMO   INSULINA   RESISTENCIA A LA INSULINA   OBESIDAD
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Epidemiologic studies have found whole-grain intake to be inversely associated with the risk of type 2 diabetes and heart disease. OBJECTIVE: We tested the hypothesis that whole-grain consumption improves insulin sensitivity in overweight and obese adults. DESIGN: This controlled experiment compared insulin sensitivity between diets (55% carbohydrate, 30% fat) including 6-10 servings/d of breakfast cereal, bread, rice, pasta, muffins, cookies, and snacks of either whole or refined grains. Total energy needs were estimated to maintain body weight. Eleven overweight or obese [body mass index (in kg/m(2)): 27-36] hyperinsulinemic adults aged 25-56 y participated in a randomized crossover design. At the end of each 6-wk diet period, the subjects consumed 355 mL (12 oz) of a liquid mixed meal, and blood samples were taken over 2 h. The next day a euglycemic hyperinsulinemic clamp test was administered. RESULTS: Fasting insulin was 10% lower during consumption of the whole-grain than during consumption of the refined-grain diet (mean difference: -15 +/- 5.5 pmol/L; P = 0.03). After the whole-grain diet, the area under the 2-h insulin curve tended to be lower (-8832 pmol.min/L; 95% CI: -18720, 1062) than after the refined-grain diet. The rate of glucose infusion during the final 30 min of the clamp test was higher after the whole-grain diet (0.07 x 10(-4) mmol.kg(-1).min(-1) per pmol/L; 95% CI: 0.003 x 10(-4), 0.144 x 10(-4)). CONCLUSION: Insulin sensitivity may be an important mechanism whereby whole-grain foods reduce the risk of type 2 diabetes and heart disease.

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23/53
Glycemic index and disease / FX Pi Sunyer.-- pp. 290-8.-- En: American Journal of Clinical Nutrition.-- 75, 5 (2002)
Notas de Contenido:
Material no impreso
GLUCOSA DE LA SANGRE   ENFERMEDADES CARDIOVASCULARES   DIABETES MELLITUS TIPO I   DIABETES MELLITUS TIPO II   CARBOHIDRATOS EN LA DIETA   INGESTION DE ALIMENTOS   INSULINA   RESISTENCIA A LA INSULINA   OBESIDAD
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    It has been suggested that foods with a high glycemic index are detrimental to health and that healthy people should be told to avoid these foods. This paper takes the position that not enough valid scientific data are available to launch a public health campaign to disseminate such a recommendation. This paper explores the glycemic index and its validity and discusses the effect of postprandial glucose and insulin responses on food intake, obesity, type 1 diabetes, and cardiovascular disease. Presented herein are the reasons why it is premature to recommend that the general population avoid foods with a high glycemic index.

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24/53
Insulin resistance in obesity / B Caballero.-- pp. 131-36.-- En: Archivos Latinoamericanos de Nutrición.-- 42, 3 suppl (1992)
Notas de Contenido:
Revista en estanteria
HIPERTENSION   RESISTENCIA A LA INSULINA   OBESIDAD   RECEPTORES DE INSULINA
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata




25/53
Regional body fat distribution and insulin resistance during adolescent pregnancy / C Stevens Simon; P Thureen; J Barrett; E Stamm.-- pp. 563-5.-- En: Journal of the American Dietetic Association.-- 102, 4 (2002)
Notas de Contenido:
Material no impreso
TEJIDO ADIPOSO   ADOLESCENTE   PESO AL NACER   CONSTITUCION CORPORAL   INDICE DE MASA CORPORAL   RESISTENCIA A LA INSULINA   EMBARAZO   EMBARAZO EN ADOLESCENCIA   AUMENTO DE PESO   GROSOR DE PLIEGUES CUTANEOS
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

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26/53
Hypertension in pregnancy: a manifestation of the insulin resistance syndrome? / CG Solomon; EW Seely.-- pp. 232-9.-- En: Hypertension.-- 37, 2 (2001)
Notas de Contenido:
Material no impreso
HIPERTENSION   RESISTENCIA A LA INSULINA   PREECLAMPSIA   EMBARAZO   COMPLICACIONES CARDIOVASCULARES DEL EMBARAZO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Pregnancy-induced hypertension (PIH), which includes both gestational hypertension and preeclampsia, is a common and morbid pregnancy complication for which the pathogenesis remains unclear. Emerging evidence suggests that insulin resistance, which has been linked to essential hypertension, may play a role in PIH. Conditions associated with increased insulin resistance, including gestational diabetes, polycystic ovary syndrome, and obesity, may predispose to hypertensive pregnancy. Furthermore, metabolic abnormalities linked to the insulin resistance syndrome are also observed in women with PIH to a greater degree than in normotensive pregnant women: These include glucose intolerance, hyperinsulinemia, hyperlipidemia, and high levels of plasminogen activator inhibitor-1, leptin, and tumor necrosis factor-alpha. These observations suggest the possibility that insulin resistance may be involved in the pathogenesis of PIH and that approaches that improve insulin sensitivity might have benefit in the prevention or treatment of this syndrome, although this requires further study.

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Free fatty acids, insulin resistance, and pregnancy / E Sivan; G Boden.-- pp. 319-22.-- En: Current Diabetes Reports.-- 3, 4 (2003)
Notas de Contenido:
Material no impreso
CARBOHIDRATOS   DIABETES GESTACIONAL   ACIDOS GRASOS NO ESTERIFICADOS   RESISTENCIA A LA INSULINA   LIPIDOS   EMBARAZO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Acute elevation of plasma free fatty acid (FFA) levels causes insulin resistance to rise dose dependently in pregnant and nonpregnant women. Plasma FFA levels are commonly elevated during late pregnancy, partly due to rising blood levels of lipolytic placental hormones, and are a likely cause for much of the increase in insulin resistance occurring at that time in all pregnant women. Plasma FFA levels are similar or higher and the insulin resistance is comparable or more severe in women with gestational diabetes mellitus (GDM) than in nondiabetic pregnant women. In contrast to healthy pregnant women, insulin secretion in women with GDM is defective and, therefore, is unable to rise adequately to compensate for the insulin resistance; the result is hyperglycemia. The mechanism by which elevated plasma FFA levels cause insulin resistance in skeletal muscle includes intramyocellular accumulation of diacylglycerol, which activates protein kinase C (the b II and d isoforms). This results in reduction of tyrosine phosphorylation of the insulin receptor substrate-1 and inhibits activation of phosphoinositol-3 kinase, an enzyme that is essential for normal insulin-stimulated glucose uptake.

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Hormones and insulin resistance during pregnancy / EA Ryan.-- pp. 1777-8.-- En: Lancet.-- 362, 9398 (2003)
Notas de Contenido:
Material no impreso
GLUCOSA DE LA SANGRE   DIABETES MELLITUS TIPO II   EXPRESION GENICA   RESISTENCIA A LA INSULINA   ISLOTES DE LANGERHANS   EMBARAZO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

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Glycemic treatment: control of glycemia / ZT Bloomgarden.-- pp. 1227-34.-- En: Diabetes Care.-- 27, 5 (2004)
Notas de Contenido:
Material no impreso
INDICE GLICEMICO   OBESIDAD   DIABETES MELLITUS TIPO II   RESISTENCIA A LA INSULINA
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

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Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulinresistant subjects / A Harbis; S Perdreau; S Vincent Baudry; M Charbonnier; MC Bernard; D Raccah; et.al..-- pp. 896-902.-- En: American Journal of Clinical Nutrition.-- 80 (2004)
Notas de Contenido:
Material no impreso
INDICE GLICEMICO   OBESIDAD   RESISTENCIA A LA INSULINA   CARBOHIDRATOS EN LA DIETA   AREA BAJO LA CURVA   GLUCOSA
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Background: Exacerbated postprandial lipemia is a risk factor for cardiovascular disease and is linked to insulin status. Limited data on the effect of dietary carbohydrate on postprandial lipoprotein accumulation are available. Objective:Wetested the hypothesis that dietary carbohydrates with different glucose availability alter postprandial lipoprotein metabolism differently in obese, insulin-resistant subjects. Design: After an overnight fast, 9 subjects with central obesity and insulin resistance but normal triacylglycerolemia randomly ingested 2 test meals with comparable amounts of fat (28-29 g) and digestible carbohydrate (91-94 g) but with different quantities of slowly available glucose (SAG) in cereal products (17 or 2 g SAG/100 g for biscuits and wheat flakes, respectively). Blood samples were collected before and for 6 h after meal intakes. Results: The postmeal 0-2-h areas under the curve (AUCs) for glycemia and insulinemia were significantly lower (P < 0.05) after the biscuit meal than after the flakes meal. Plasma triacylglycerol concentrations increased significantly after the flakes meal but not after the biscuit meal (1.5-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-100 concentrations in the triacylglycerolrich lipoprotein fraction increased significantly 2 h after the flakes meal but not after the biscuit meal (3-fold higher 0-6-hAUCfor the flakes meal). Apolipoprotein B-48 concentrations increased (P <0.05) 4 h after the flakes meal but not after the biscuit meal (2.3-fold higher 0-6-h AUC for the flakes meal).

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Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the framingham offspring cohort / NM McKeown; JB Meigs; S Liu; E Saltzman; PW Wilson; PF Jacques.-- pp. 538-546.-- En: Diabetes Care.-- 27, 2 (2004)
Notas de Contenido:
Material no impreso
CARBOHIDRATOS EN LA DIETA   FIBRA EN LA DIETA   RESISTENCIA A LA INSULINA   INDICE GLUCEMICO   SINDROME X METABOLICO   PRESION SANGUINEA   ESTUDIOS DE COHORTES
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    OBJECTIVE: The aim of this study was to examine the relation between carbohydrate-related dietary factors, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. RESEARCH DESIGN AND METHODS: We examined cross-sectional associations between carbohydrate-related dietary factors, insulin resistance, and the prevalence of the metabolic syndrome in 2,834 subjects at the fifth examination (1991-1995) of the Framingham Offspring Study. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated using the following formula (fasting plasma insulin x plasma glucose)/22.5. The metabolic syndrome was defined using the National Cholesterol Education Program criteria. RESULTS: After adjustment for potential confounding variables, intakes of total dietary fiber, cereal fiber, fruit fiber, and whole grains were inversely associated, whereas glycemic index and glycemic load were positively associated with HOMA-IR. The prevalence of the metabolic syndrome was significantly lower among those in the highest quintile of cereal fiber (odds ratio [OR] 0.62; 95% CI 0.45-0.86) and whole-grain (0.67; 0.48-0.91) intakes relative to those in the lowest quintile category after adjustment for confounding lifestyle and dietary factors. Conversely, the prevalence of the metabolic syndrome was significantly higher among individuals in the highest relative to the lowest quintile category of glycemic index (1.41; 1.04-1.91). Total carbohydrate, dietary fiber, fruit fiber, vegetable fiber, legume fiber, glycemic load, and refined grain intakes were not associated with prevalence of the metabolic syndrome...continua.

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Chilldhood obesity and insulin-resistant syndrome / CS Yensel; D Preud`Homme; DM Curry.-- pp. 238-46.-- En: Journal of Pediatric Nursing.-- 19, 4 (2004)
Notas de Contenido:
Material no impreso
OBESIDAD   RESISTENCIA A LA INSULINA   NIÑO   DIABETES MELLITUS TIPO II
Categoría geográfica: ESTADOS UNIDOS  
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Childhood obesity has become a national concern, health threat, and is increasing at an alarming rate. Obesity is associated with many comorbidities that last into adulthood. Insulin-resistant syndrome (IRS) is developing in growing numbers of obese children. Pediatric nurses play a unique and important role in identifying which children are at risk for obesity and IRS. This article gives current information on what tools to use, how to identify those children, and the interventions needed.

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Pediatric obesity and insulin resistance: Chronic disease risk and implications for treatment and prevention beyond body weight modification / ML Cruz; GQ Shaibi; MJ Weigensberg; D Spruijt-Metz; GD Ball; MI Goran
OBESIDAD   RESISTENCIA A LA INSULINA   ENFERMEDAD CRONICA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-6288
Tipo de Material:
Separata

    Abstract The study of childhood obesity has continued to grow exponentially in the past decade. This has been driven in part by the increasing prevalence of this problem and the widespread potential effects of increased obesity in childhood on lifelong chronic disease risk. The focus of this review is on recent findings regarding the link between obesity and disease risk during childhood and adolescence. We describe recent reports relating to type 2 diabetes in youth (2), prediabetes (69, 166), metabolic syndrome (33, 35), polycystic ovarian syndrome (77), and nonalcoholic fatty liver disease (58, 146), and the mediating role of insulin resistance in these conditions. In addition, we review the implications of this research for the design of more effective treatment and prevention strategies that focus more on the improvement of obesity-related metabolic abnormalities and chronic disease risk reduction than on the conventional energy balance approach that focuses on weight management.

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Insulin resistance-associated cardiovascular disease: potential benefits of conjugated linoleic acid / DV Aminot Gilchrist; HD Anderson.-- pp. 1159S-63S.-- En: American Journal of Clinical Nutrition.-- 79, 6 Suppl (2004)
Notas de Contenido:
Material no impreso
ALBUMINA SERICA   ENFERMEDADES CARDIOVASCULARES   DIABETES MELLITUS TIPO II   SUPLEMENTOS DIETETICOS   HIPERLIPIDEMIA   RESISTENCIA A LA INSULINA   OBESIDAD
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Type 2 diabetes and associated cardiovascular disease have reached global epidemic proportions. Recent data from the World Health Organization Multinational Study of Vascular Disease in Diabetes indicate that cardiovascular disease is the leading cause of mortality (52% of deaths) in individuals with type 2 diabetes. Although insulin resistance plays a critical role in the pathogenesis of type 2 diabetes-related cardiovascular disease, other related risk factors often cluster in a single patient; the combination of insulin resistance and these risk factors is known as the metabolic syndrome. According to the World Health Organization definition, this constellation of risk factors includes hypertension, elevated plasma triacylglycerol, reduced HDL cholesterol, central obesity, and microalbuminuria. The Multiple Risk Factor Intervention Trial showed that, although diabetes or insulin resistance is an independent risk factor for cardiovascular disease mortality, these other components of the metabolic syndrome confer additive risk. Thus, to effectively address cardiovascular disease in persons with diabetes, intervention would ideally target all these factors. Conjugated linoleic acid could represent a candidate agent. The therapeutic potential of conjugated linoleic acid against insulin resistance-associated cardiovascular disease is discussed on the basis of the reported effects of conjugated linoleic acid on individual components of the metabolic syndrome.

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El síndrome metabólico: un concepto en evolución / CA Aguilar Salinas; R Rojas; FJ Gómez Pérez; A Franco; G Olaiz; JA Rull.-- pp. S41-8.-- En: Gaceta Médica de México.-- 140, 2 (2004)
Notas de Contenido:
Material no impreso
SINDROME X METABOLICO   RESISTENCIA A LA INSULINA   ESTEATOHEPATITIS NO ALCOHOLICA
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    El concepto síndrome metabólico pretende integrar en una enfermedad a las consecuencias biológicas de la resistencia a la insulina y de sus patologías asociadas. El objetivo de esta revisión es discutir las fortalezas y debilidades de las definiciones actuales de la enfermedad,
    su epidemiología y su relación con la esteatohepatitis no alcohólica (EHNA). Las definiciones propuestas por la Organización Mundial de la Salud (OMS) y por el Programa Nacional de Educación en Colesterol (NCEP) son específicas pero poco sensibles. Además, los puntos de corte empleados debieran variar dependiendo del grupo étnico; en poblaciones no caucásicas, no existe concordancia entre las definiciones. Por ejemplo, en un estudio con muestreo poblacional Mexicano, la prevalencia fue de 13.61% para el criterio de la OMS y de 26.6% para el criterio del NCEPIII. Los sujetos diagnosticados con el criterio de la OMS tenían una forma más severa de síndrome metabólico. La EHNA es la causa más frecuente por la que se encuentran concentraciones altas de transaminasas. Comparte elementos
    de su fisiopatología con el síndrome metabólico; su prevalencia es significativamente mayor en el síndrome metabólico que en el resto de la población general. La EHNA parece ser la manifestación hepática del síndrome.

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The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity / ML Cruz; MJ Weigensberg; TT Huang; G Ball; GQ Shaibi; MI Goran.-- pp. 108-13.-- En: The Journal of Clinical Endocrinology and Metabolism.-- 89, 1 (2004)
Notas de Contenido:
Material no impreso
GLUCOSA DE LA SANGRE   PRESION SANGUINEA   DIABETES MELLITUS TIPO II   FAMILIA   RESISTENCIA A LA INSULINA   SINDROME X METABOLICO   TRIGLICERIDOS
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    The prevalence of the metabolic syndrome is highest among Hispanic adults. However, studies exploring the metabolic syndrome in overweight Hispanic youth are lacking. Subjects were 126 overweight children (8-13 yr of age) with a family history for type 2 diabetes. The metabolic syndrome was defined as having at least three of the following: abdominal obesity, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, hypertension, and/or impaired glucose tolerance. Insulin sensitivity was determined by the frequently sampled iv glucose tolerance test and minimal modeling. The prevalence of abdominal obesity, low HDL cholesterol, hypertriglyceridemia, systolic and diastolic hypertension, and impaired glucose tolerance was 62, 67, 26, 22, 4, and 27%, respectively. The presence of zero, one, two, or three or more features of the metabolic syndrome was 9, 22, 38, and 30%, respectively. After controlling for body composition, insulin sensitivity was positively related to HDL cholesterol (P < 0.01) and negatively related to triglycerides (P < 0.001) and systolic (P < 0.01) and diastolic blood pressure (P < 0.05). Insulin sensitivity significantly decreased (P < 0.001) as the number of features of the metabolic syndrome increased. In conclusion, overweight Hispanic youth with a family history for type 2 diabetes are at increased risk for cardiovascular disease and type 2 diabetes, and this appears to be due to decreased insulin sensitivity. Improving insulin resistance may be crucial for the prevention of chronic disease in this at-risk population.

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Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Bogalusa Heart Study / SR Srinivasan; MG Frontini; GS Berenson; Bogalusa Heart Study.-- pp. 443-50.-- En: Metabolism.-- 52, 4 (2003)
Notas de Contenido:
Material no impreso
RESISTENCIA A LA INSULINA   GLUCOSA DE LA SANGRE   DIABETES MELLITUS TIPO II   ADOLESCENTE   ADULTO   NIÑO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    The occurrence of metabolic abnormalities related to insulin resistance syndrome in nondiabetic offspring of type 2 diabetic parents is known. However, information is lacking on the timing and the course of development of the components of this syndrome from childhood to adulthood in the offspring of parents with diabetes. This aspect was examined in a community-based cohort with (n = 303) and without (n = 1,136) a parental history of type 2 diabetes followed longitudinally since childhood (ages 4 to 17 years; mean follow-up period, 15 years) by repeated surveys. Offspring with parental diabetes versus those without such history had significantly excess generalized and truncal adiposity as measured by body mass index (BMI) and subscapular skinfold beginning in childhood, higher levels of fasting insulin and glucose and homeostasis model assessment index of insulin resistance (HOMA-IR) from adolescence, and higher levels of low-density lipoprotein (LDL) cholesterol and triglycerides and lower levels of high-density lipoprotein (HDL) cholesterol in adulthood....continua.

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Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus / NF Butte.-- pp. 1256S-61S.-- En: American Journal of Clinical Nutrition.-- 71, 5 Suppl (2000)
Notas de Contenido:
Material no impreso
DIABETES GESTACIONAL   CARBOHIDRATOS EN LA DIETA   GRASAS EN LA DIETA   RESISTENCIA A LA INSULINA   EMBARAZO   EDAD GESTACIONAL
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    This article reviews maternal metabolic strategies for accommodating fetal nutrient requirements in normal pregnancy and in gestational diabetes mellitus (GDM). Pregnancy is characterized by a progressive increase in nutrient-stimulated insulin responses despite an only minor deterioration in glucose tolerance, consistent with progressive insulin resistance. The hyperinsulinemic-euglycemic glucose clamp technique and intravenous-glucose-tolerance test have indicated that insulin action in late normal pregnancy is 50-70% lower than in nonpregnant women. Metabolic adaptations do not fully compensate in GDM and glucose intolerance ensues. GDM may reflect a predisposition to type 2 diabetes or may be an extreme manifestation of metabolic alterations that normally occur in pregnancy. In normal pregnant women, basal endogenous hepatic glucose production (R(a)) was shown to increase by 16-30% to meet the increasing needs of the placenta and fetus.....continua.

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Nutrición y envejecimiento / IH Rosenberg; A Sastre .--Vevey : Nestlé Nutrition, 2002.-- iv, 49 p..- Serie: Nestlé Nutrition Workshop Series, 6
ANCIANO   NUTRICION   COMPOSICION CORPORAL   RESISTENCIA A LA INSULINA   INGESTION DE ENERGIA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: 613.20838.R813.2002
Tipo de Material:
Monografias

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Manejo dietético del niño y el adolescente con hiperinsulinismo y resistencia a la insulina / ZE Zarzalejo Subero.-- pp. 32-5.-- En: Boletín de Nutrición Infantil CANIA, 15 (2007)
Notas de Contenido:
Revista en estanteria
HIPERINSULINISMO   RESISTENCIA A LA INSULINA   EVALUACION NUTRICIONAL   OBESIDAD
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata




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Obesidad e hiperinsulinismo en niños y adolescentes: ¿Una epidemia? Opciones terapéuticas / C Capriles.-- pp. 36-42.-- En: Boletín de Nutrición Infantil CANIA, 15 (2007)
Notas de Contenido:
Revista en estanteria
HIPERINSULINISMO   OBESIDAD   RESISTENCIA A LA INSULINA   ADOLESCENTE
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata




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Insulina sérica en niños y adolescentes obesos y eutróficos / ME Viso González; L Solano Rodríguez; A Sánchez; Z Portillo; D Llovera.-- p. 57-63.-- En: Anales Venezolanos de Nutrición.-- 17, 2 (2004)
RESISTENCIA A LA INSULINA   OBESIDAD   APOYO NUTRICIONAL   ADOLESCENTE   NIÑO
Categoría geográfica: VENEZUELA  
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    La insulina está íntimamente relacionada con la obesidad y sus complicaciones. Para determinar los niveles de esta hormona en niños y adolescentes, y su asociación con edad, género, estado nutricional antropométrico y consumo dietario, se evaluaron 124 niños y adolescentes (68 eutróficos y 56 obesos, edades 2-15 años). Se realizó valoración socioeconómica (Graffar-Méndez C), dietaria (recordatorios 24 horas), nutricional antropométrica y de laboratorio (insulina por ELISA). Se definió eutrófico por peso para la talla (P/T) o índice de masa corporal (IMC) y el área grasa entre percentil 10 y 90, y obesidad cuando eran superiores al percentil 90, así mismo, con el objeto de evaluar la distribución de la grasa corporal se determinó la relación cintura/muslo (RCM)...Continua.




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Type 2 diabetes in children and youth / FR Kaufman.-- pp. 659-76.-- En: Endocrinology and Metabolism Clinics of North America.-- 34, 3 (2005)
DIABETES MELLITUS TIPO II   RESISTENCIA A LA INSULINA   SINDROME X METABOLICO   NIÑO   ADOLESCENTE
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    The number of children and youth diagnosed with type 2 diabetes has increased dramatically over the last decade. Much still needs to be learned about why this epidemic is occurring presently with regard to other environmental factors that might promote insulin resistance and beta-cell failure. The TODAY trial will help to determine the best treatment strategies to improve glycemia, reduce complications, and ameliorate insulin resistance and beta-cell failure. As type 2 diabetes emerges as a worldwide public health problem, improved care for affected youth must be coupled with a focus on prevention.

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Relacion entre los factores de riesgo de enfermedades crónicas no trasmisibles y la sensibilidad a la insulina en adultos jóvenes de 18 a 39 años de la ciudad de Cali-Colombia / M Mosquera; A Pradilla; B Gracia; ML Cruz; AF Sánchez; C Aguilar de Plata.-- pp. 10-7.-- En: Archivos Latinoamericanos de Nutrición.-- 57, 1 (2007)
ENFERMEDAD CRONICA   RESISTENCIA A LA INSULINA   PRUEBA DE TOLERANCIA A LA GLUCOSA   ADOLESCENTE   ADULTO
Categoría geográfica: COLOMBIA  
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    En Colombia se desconoce la prevalencia de resistencia a insulina(RI) y factores de riesgo(FR) para el desarrollo de enfermedades crónicas no transmisibles(ECNT). El objetivo del estudio fue determinar asociación entre FR de ECNT y el grado de sensibilidad a insulina (SI)I en adultos jóvenes aparentemente sanos. Se seleccionaron por conveniencia 97 sujetos (24±4.66 años), de quienes se obtuvo historia familiar y personal, antropometría, perfil lipídico y se practicó Test Corto de Tolerancia a Insulina para determinar prevalencia de RI y factores de riesgo asociados. La media del perfil lipídico y la antropometría estuvieron dentro de límites de referencia. La SI se categorizó en Alta, Media-Alta, Media-Baja y Baja, 51% de mujeres y 41% de hombres se ubicaron en los grupos de menor sensibilidad. Se encontró diferencia entre la circunferencia de cintura y peso entre sujetos con SI Baja y Media-Baja y SI Media Alta y Alta. Los grupos con Media-Baja y Baja presentaron como mínimo tres FR....Continua.




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Esteatosis hepática, resistencia a la insulina y adiponectina en una población con obesidad / M López-Capapé; A López-Bermejo; M Alonso Blanco; E Lara Orejas; J Corbatón Blasco; R Barrio Castellanos.-- pp. 495-501.-- En: Anales de Pediatría (Barcelona).-- 71, 6 (2009)
Notas de Contenido:
Material no impreso
RESISTENCIA A LA INSULINA   ADIPONECTINA   HIGADO GRASO   OBESIDAD   NIÑO   PREESCOLAR
Ubicación: CANIA. CD   
Tipo de Material:
Separata

    INTRODUCTION: To study the clinical and laboratory relationships of fatty liver disease in a group of obese children and to investigate whether circulating adiponectin is related to fatty liver disease. PATIENTS AND METHODS: Two hundred-ninety obese patients (age 4-18 years) were studied. Baseline body mass index-standard deviation score (BMI-SDS), acanthosis nigricans, blood pressure, plasma lipids, uric acid, alanine aminotransferase (ALT) and adiponectin were assessed, and a standard oral glucose tolerance test was performed. Insulin resistance (RI) was estimated by the homeostasis model assessment (HOMA) and liver steatosis was assessed by ultrasound (US). Children were classified as having metabolic syndrome if they met three or more of the following criteria: obesity, hypertension, hypertriglyceridemia, low HDL-cholesterol and impaired glucose metabolism. RESULTS: Fifty-two subjects (18%) had fatty liver by US and 22 (8%) had elevated ALT levels (> or =40 U/L). Subjects with steatosis were significantly older (12.2+/-2.4 frente a 11.1+/-2.9 yr), heavier (BMI-SDS: 4.5+/-1.5 frente a 3.8+/-1.3), and more RI (HOMA: 3.7+/-1.5 frente a 2.4+/-1.4), but were comparable in gender, pubertal status and racial distribution to those with normal US....Continua.

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Essential fatty acids as determinants of lipid requirements in infants, children and adults / R Uauy; P Mena; A Valenzuela.-- pp. S66-77.-- En: European Journal of Clinical Nutrition.-- 53, Suppl 1 (1999)
Notas de Contenido:
Revista en estantería
METABOLISMO ENERGETICO   INGESTION DE ENERGIA   GRASAS EN LA DIETA   EICOSANOIDES   RESISTENCIA A LA INSULINA   OXIDACION-REDUCCION   PROSTAGLANDINAS   LECHE HUMANA   NIÑO   ADULTO
Ubicación: CANIA. CD   
Tipo de Material:
Separata

    Essential fatty acids (EFA) are the indispensable component of the lipid supply beyond the provision of energy as a fuel for oxidation. They serve as dietary precursors for the formation of prostanoids and other eicosanoids thus are of great significance in health and modulation of disease conditions. Eicosanoids are powerful autocrine and paracrine regulators of cell and tissue functions: thrombocyte aggregation, inflammatory reactions and leukocyte functions, vasoconstriction and vasodilatation, blood pressure, bronchial constriction, and uterine contraction......Continua.

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A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome / DE Williams; AT Prevost; MJ Whichelow; BD Cox; NE Day; NJ Wareham.-- pp. 257-66.-- En: British Journal of Nutrition.-- 83, 3 (2000)
INTOLERANCIA A LA GLUCOSA   DIABETES MELLITUS TIPO II   RESISTENCIA A LA INSULINA   CONSUMO DE BEBIDAS ALCOHOLICAS   TABAQUISMO   ADULTO
Ubicación: CANIA. CD   
Tipo de Material:
Separata

    Previous epidemiological studies have demonstrated relationships between individual nutrients and glucose intolerance and type 2 diabetes, but the association with the overall pattern of dietary intake has not previously been described. In order to characterize this association, 802 subjects aged 40-65 years were randomly selected from a population-based sampling frame and underwent a 75 g oral glucose-tolerance test. Principal component analysis was used to identify four dietary patterns explaining 31.7% of the dietary variation in the study cohort. These dietary patterns were associated with other lifestyle factors including socio-economic group, smoking, alcohol intake and physical activity. Component 1 was characterized by a healthy balanced diet with a frequent intake of raw and salad vegetables, fruits in both summer and winter, fish, pasta and rice and low intake of fried foods, sausages, fried fish, and potatoes. This component was negatively correlated with central obesity, fasting plasma glucose, 120 min non-esterified fatty acid and triacylglycerol, and positively correlated with HDL-cholesterol. It therefore appears to be protective for the metabolic syndrome....Continúa.

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Genetics of the metabolic syndrome / L Groop.-- pp. S39-48.-- En: British Journal of Nutrition.-- 83, Suppl 1 (2000)
DIABETES MELLITUS TIPO II   HIPERTENSION   RESISTENCIA A LA INSULINA   LEPTINA   OBESIDAD
Ubicación: CANIA. CD   
Tipo de Material:
Separata

    The clustering of cardiovascular risk factors such as abdominal obesity, hypertension, dyslipidaemia and glucose intolerance in the same persons has been called the metabolic or insulin-resistance syndrome. In 1998 WHO proposed a unifying definition for the syndrome and chose to call it the metabolic syndrome rather than the insulin-resistance syndrome. Although insulin resistance has been considered as a common denominator for the different components of the syndrome, there is still debate as to whether it is pathogenically involved in all of the different components of the syndrome....Continúa.

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Primary lipodystrophies / J Capeau; J Magré; O Lascols; M Caron; V Béréziat; C Vigouroux.-- 10-20.-- En: Annales d’Endocrinologie.-- 68, 1 (2007)
RESISTENCIA A LA INSULINA   HIPERANDROGENISMO   DISLIPIDEMIA   DIABETES
Ubicación: CANIA. CD   
Tipo de Material:
Separata

    Primary lipodystrophies represent a heterogeneous group of very rare diseases with a prevalence of less than 1 case for 100.000, inherited or acquired, caracterized by a loss of body fat either generalized or localized (lipoatrophy). In some forms, lipoatrophy is associated with a selective hypertrophy of other fat depots. Clinical signs of insulin resistance are often present: acanthosis nigricans, signs of hyperandrogenism. All lipodystrophies are associated with dysmetabolic alterations with insulin resistance, altered glucose tolerance or diabetes and hypertriglyceridemia leading to a risk of acute pancreatitis...Continua.

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Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk / M de Onis; C Martínez-Costa; F Núñez; G Nguefack-Tsague; A Montal; J Brines.-- pp. 625-30.-- En: Public Health Nutrition.-- 16, 4 (2013)
ENFERMEDADES CARDIOVASCULARES   OBESIDAD   PRESION ARTERIAL   COLESTEROL LDL   ANALISIS POR CONGLOMERADOS   HIPERTENSION   RESISTENCIA A LA INSULINA   ACIDO URICO
Categoría geográfica: ESPAÑA  
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
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    OBJECTIVE: To examine the association between cardiovascular risk and childhood overweight and obesity using the BMI cut-offs recommended by the WHO. DESIGN: Children were classified as normal weight, overweight and obese according to the WHO BMI-for-age reference. Blood pressure, lipids, glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR) and uric acid levels were compared across BMI groups. ANOVA and tests of linearity were used to assess overall mean differences across groups. Crude and adjusted odds ratios were calculated for adverse plasma levels of biochemical variables. SETTING: Paediatric care centres. SUBJECTS: Children (n 149) aged 8-18 years.

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