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The relationship between bone turnover and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa / M Hotta; I Fukuda; K Sato; N Hizuka; T Shibasaki; K Takano.-- p. 200-6.-- En: The Journal of Clinical Endocrinology and Metabolism.-- 85, 1 (2000)
ADOLESCENTE   ADULTO   ANOREXIA NERVIOSA   MARCADORES BIOLOGICOS   INDICE DE MASA CORPORAL   PESO CORPORAL   REABSORCION OSEA   HUESOS   PROTEINA 3 DE ENLACE A FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA   FACTOR I DEL CRECIMIENTO SIMILAR A LA INSULINA   PROTEINA 2 DE ENLACE A FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA   PROTEINAS DE ENLACE A FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA   ESTADO NUTRICIONAL   OSTEOCALCINA   NUTRICION PARENTERAL TOTAL
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-3802
Tipo de Material:
Separata

    Malnutrition is one of the risk factors for bone loss in patients with anorexia nervosa (AN). To clarify the effects of nutritional status on bone metabolism, we examined the relationship between serum levels of nutritional indicators [insulin-like growth factor I (IGF-I), IGF-binding protein-2 (IGFBP-2), and IGFBP-3] and markers for bone metabolism [serum osteocalcin and urinary excretion of C-terminal telopeptide of collagen type I (CrossLaps)] in 45 AN out-patients, including 8 severely malnourished patients who required hospitalization and iv hyperalimentation (IVH). Compared to healthy subjects, serum IGF-I and IGFBP-3 were lower, whereas IGFBP-2 was higher in out-patients who had a body mass index (BMI) less than 16.5 kg/m2. In these patients, urinary excretion of CrossLaps, a marker of bone resorption, was higher, whereas serum osteocalcin, a marker of bone formation, was lower than those in control subjects. All of these parameters were normal in patients whose BMI ranged from 16.5-18.5 kg/m2. Serum levels of osteocalcin correlated positively with BMI (r = 0.512; P<0.0001), IGF-I (r = 0.558; P<0.0001), and IGFBP-3 (r = 0.369; P<0.001) in AN out-patients. In the 8 severely malnourished AN patients, serum levels of IGF-I and osteocalcin significantly increased 3 and 7 days, respectively, after the start of a 5-week IVH therapy regimen and reached normal levels within 5 weeks, accompanied by still elevated urinary excretion of CrossLaps. The present study demonstrates that an improvement in nutritional status in AN patients during IVH therapy rapidly increases the serum IGF-I levels, followed by a progressive increase in osteocalcin, suggesting immediate start of bone formation. However, increased bone resorption appears to continue for at least 5 weeks.




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IGF-I, IGF-II, free IGF-I and IGFBP-1, -2 and -3 levels in venous cord blood: relationship to birthweight, length and gestational age in healthy newborns / D Klauwer; WF Blum; S Hanitsch; W Rascher; PD Lee; W Kiess.-- pp. 826-33.-- En: Acta Paediatrica: an International Journal of Paediatrics.-- 86, 8 (1997)
PESO AL NACER   SANGRE FETAL   EDAD GESTACIONAL   RECIEN NACIDO   PROTEINA 3 DE ENLACE A FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA   PROTEINA 2 DE ENLACE A FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA   PROTEINA DE ENLACE DE FACTOR DE CRECIMIENTO   FACTOR I DEL CRECIMIENTO SIMILAR A LA INSULINA
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-6039
Tipo de Material:
Separata

    The insulin-like growth factors (IGF-I and IGF-II) and their binding proteins (IGFBPs) have been implicated in regulating fetal growth and development. The aim of this study was to determine whether fetal IGFs correlate with auxologic data at birth and/or gestational age. Venous cord blood was obtained from 138 healthy newborns immediately after birth and clinical data were recorded using a standardized data sheet. For the determination of IGF-I and IGF-II, IGFBP-blocked radioimmunoassays were used. A coated-tube immunoradiometric assay was applied for the measurement of free IGF-I. IGFBP-1, -2, and -3 were measured using specific radioimmunoassays. IGF-I levels were 61 +/- 21 ng ml(-1), median 61 ng ml(-1), range 19-114 ng ml(-1); IGF-II levels were 466 +/- 80 ng ml(-1), median 457 ng ml(-1), range 311-701 ng ml(-1); free IGF-I levels were 2.4 +/- 1.8 ng ml(-1), median 1.8 ng ml(-1), range 0.4-7.8 ng ml(-1). The concentration of IGFBP-1 was 144 +/- 110 ng ml(-1), median 113 ng ml(-1), range 20-626 ng ml(-1); that of IGFBP-2 was 1165 +/- 455 ng ml(-1), median 1119 ng ml(-1), range 440-3466 ng ml(-1). IGFBP-3 levels were 1272 +/- 280 ng ml(-1), median 1272 ng ml(-1), range 600-1966 ng ml(-1). IGF-I levels correlated significantly with IGFBP-3 levels (r = 0.71), birthweight (r = 0.48) and birth length (r = 0.37). There were significant inverse correlations between IGF-I and both IGFBP-1 (r = -0.45) and IGFBP-2 (r = -0.62). Although free IGF-I levels correlated (r = 0.71) with total IGF-I, only marginally significant correlations were found between free IGF-I and birthweight (r = 0.25)...Continúa.





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