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Exposure to environmental tobacco smoke in nonsmoking pregnant women in relation to birth weight / M Rebagliato; C du V Florey; F Bolumar.-- p.531-537.-- En: American Journal of Epidemiology.-- 142, 5 (1995)
ADULTO   PESO AL NACER   ESTUDIOS DE COHORTES   COTININA   EXPOSICION A RIESGOS AMBIENTALES   RECIEN NACIDO   ENTREVISTAS   EMBARAZO   ESTUDIOS PROSPECTIVOS   ANALISIS DE REGRESION   SALIVA   CONTAMINACION POR HUMO DE TABACO
Categoría geográfica: ESPAÑA  
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-4573
Tipo de Material:
Separata




2/6
Medical genetics: 1. Clinical teratology in the age of genomics / JE Polifka; JM Friedman.-- p. 265-73.-- En: Canadian Medical Association Journal.-- 167, 3 (2002)
Notas de Contenido:
Material no impreso
ADULTO   CONSUMO DE BEBIDAS ALCOHOLICAS   ANTICONVULSIVOS   INFORME DE CASO   EXPOSICION A RIESGOS AMBIENTALES   EPILEPSIA   FEMENINO   CONSEJO GENETICO   PREDISPOSICION GENETICA A LA ENFERMEDAD   TAMIZAJE GENETICO   GENETICA MEDICA   HUMANO   EMBARAZO   MEDICION DE RIESGO   TABAQUISMO   TERATOGENOS   ACIDO VALPROICO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogenesis, as well as known genetic susceptibilities to teratogenic effects, with a special focus on antiepileptic drugs. We discuss general principles of risk counselling and risk reduction, and we describe several long-known teratogens, as well as several exposures recognized only recently to have teratogenic potential.

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3/6
Data torturing / JL Mills.-- pp. 1196-9.-- En: The New England Journal of Medicine.-- 329, 16 (1993)
INTERVALOS DE CONFIANZA   INTERPRETACION ESTADISTICA DE DATOS   EXPOSICION A RIESGOS AMBIENTALES   PROBABILIDAD   PROYECTOS DE INVESTIGACION
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-6001
Tipo de Material:
Separata




4/6
Breast-feeding and maternal drug use / B Bailey; S Ito.-- pp. 41-54.-- En: Clínicas Pediátricas de Norteamérica.-- 44, 1 (1997)
Notas de Contenido:
Revista en estanteria
LACTANCIA MATERNA   EXPOSICION A RIESGOS AMBIENTALES   PREPARACIONES FARMACEUTICAS   LACTANTE   RECIEN NACIDO
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    Because drugs are almost never tested for use in lactating women before marketing, uncertainties about their safety for breast-fed infants often cause anxiety and unnecessary interruption of breast-feeding. Based on an understanding of mechanisms and principles of drug excretion into milk, we can rationally minimize the uncertainties. As described in this article, the infant exposure levels may be predicted using actual data on drug concentrations or even theoretic equations. Although the approach has to be rigorously tested in future studies, informed decisions on breast-feeding during maternal drug therapy are now within reach of resourceful health professionals. As more outcome data become available, remaining uncertainties will be addressed.




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Atypical cutaneous leishmaniasis in Central America: possible interaction between infectious and environmental elements / J Convit; M Ulrich; M Pérez; J Hung; J Castillo; H Rojas; et.al..-- pp. 13-7.-- En: Transactions of the Royal Society of Tropical Medicine and Hygiene.-- 99, 1 (2005)
LEISHMANIASIS CUTANEA   DIOXIDO DE SILICIO   PIEL   EXPOSICION A RIESGOS AMBIENTALES   ADOLESCENTE   ADULTO
Categoría geográfica: COSTA RICA   NICARAGUA  
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-6606
Tipo de Material:
Separata

    Biopsies of 71 cases of atypical cutaneous leishmaniasis from Costa Rican patients were evaluated by histopathological procedures and attempts were made to culture Leishmania from nine biopsies. Leishmanin skin tests were carried out in 31 patients and 112 healthy individuals. Additional biopsies from 19 patients from Nicaragua were evaluated by routine histopathology. Ten biopsies were studied by confocal and nine by scanning electron microscopy. Inorganic material was analysed using an electron probe for microanalysis. Leishmania parasites were isolated from only two biopsies, but 90.3% of the patients from Costa Rica were leishmanin-positive, as were 27.7% of healthy individuals. Routine histopathological studies revealed naked granulomas formed by differentiated macrophages. Abundant inorganic material was observed in sections examined by confocal microscopy. Electron probe analysis revealed that silica and aluminium were the predominant elements in large particles. We postulate that the presence of this inorganic material, possibly of volcanic origin, in the skin may modulate the immunological response to Leishmania and may inhibit visceralization in the cases caused by Leishmania chagasi.




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Inorganic particles in the skin of inhabitants of volcanic areas of Central America: their possible immunomodulatory influence in leishmaniasis and leprosy / J Convit; M Ulrich; J Castillo; H De Lima; M Pérez; N Caballero; et.al..-- pp. 734-9.-- En: Transactions of the Royal Society of Tropical Medicine and Hygiene.-- 100, 8 (2006)
LEISHMANIASIS CUTANEA   DIOXIDO DE SILICIO   PIEL   EXPOSICION A RIESGOS AMBIENTALES   ADOLESCENTE   ADULTO
Categoría geográfica: GUATEMALA   NICARAGUA   HONDURAS  
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-6607
Tipo de Material:
Separata

    We have evaluated biopsies from patients with atypical nodular and typical ulcerated lesions of cutaneous leishmaniasis, from leishmanin reactions and skin from normal individuals from Nicaragua, Honduras and Guatemala for the presence of inorganic particles using confocal microscopy with a polarised light source and conventional histopathological techniques. Analysis by semiquantitative confocal microscopy permitted the demonstration of significantly larger numbers of particles in atypical lesions. Silica and aluminium, important components of these particles, were less abundant in particles from normal skin. The histology of these atypical lesions, characterised by 'naked' sarcoidal granulomas with epithelioid differentiation but very few lymphocytes, was very similar to the histological reaction observed after 14 days in persisting inflammation at leishmanin skin test sites. The presence of these unusual lesions in areas of Central American countries characterised by the presence of large amounts of volcanic ash, as well the unexpectedly low prevalence of leprosy in Central America, suggest that environmental factors may contribute significantly to the frequency and clinical manifestations of these infections. Among possible environmental features, the presence of inorganic particles with immunomodulatory properties in the skin may be a significant factor.





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