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Lowering of HDL2-cholesterol and lipoprotein A-I particle levels by increasing the ratio of polyunsaturated to saturated fatty acids / F Fumeron; L Brigant; HJ Parra; JM Bard; JC Fruchart.-- pp. 655-9.-- En: American Journal of Clinical Nutrition.-- 53, 3 (1991)
ADULTO   ANALISIS DE VARIANZA   APOLIPOPROTEINA A-I   APOLIPOPROTEINAS A   APOLIPOPROTEINAS B   CORONARIOPATIA   GRASAS EN LA DIETA   GRASAS NO SATURADAS EN LA DIETA   LIPOPROTEINAS HDL   LIPOPROTEINAS DEL COLESTEROL HDL
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-5689
Tipo de Material:
Separata

    The protective role of high-density lipoproteins (HDLs) has been attributed to the subfractions HDL2 (according to the density) and lipoprotein A-I (LpA-I) (according to the composition in apolipoproteins). We investigated the effect of a high ratio of polyunsaturated to saturated fatty acids (P:S) on these subfractions in a homogeneous group of young adult males. Two prescribed diets were consumed successively at the subjects' homes for 3 wk each in a random order; one diet contained 70 g butter (P:S 0.2, diet B), the other contained 70 g sunflower margarine (P:S 1.1, diet M). Total calorie, fat, and cholesterol intakes were similar for the two diets. Cholesterol and apolipoprotein B in serum and in low-density lipoproteins (LDLs) were lower with diet M than with diet B. However, significant decreases in protective subfractions of HDL, HDL2, and LpA-I were observed. This undesirable effect of the diet with a high P:S could cancel the benefits of lowering the LDL-cholesterol concentrations.




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Dietary treatment for familial hypercholesterolemia--differential effects of dietary soy protein according to the apolipoprotein E phenotypes / A Gaddi; A Ciarrocchi; A Matteucci; et.al..-- pp. 1191-6.-- En: American Journal of Clinical Nutrition.-- 53, 5 (1991)
ADULTO   APOLIPOPROTEINA A-I   APOLIPOPROTEINAS A   APOLIPOPROTEINAS B   APOLIPOPROTEINAS E   COLESTEROL   PROTEINAS EN LA DIETA   HUMANO   HIPERCOLESTEROLEMIA FAMILIAR   LIPOPROTEINAS HDL   LIPOPROTEINAS DEL COLESTEROL HDL   LIPOPROTEINAS DEL COLESTEROL LDL   PROTEINAS DE SOYA   SOYA   PROTEINAS VEGETALES
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-5695
Tipo de Material:
Separata

    Familial hypercholesterolemia, one form of type IIa hyperlipidemia, usually responds poorly to standard low-lipid diets. To define the responsiveness to a soy-protein diet in this disease, one homozygous and twenty heterozygous type IIa patients were submitted to a 4-wk traditional hypocholesterolemic diet followed by 4 wk in which animal protein was substituted with texturized soy protein. Soy was then withdrawn for a further 4 wk. No significant changes in plasma lipids were observed during low-lipid diets. The soy diet, however, caused a marked decrease in total (-20.8%) and low-density-lipoprotein (-25.8%) cholesterol and in apolipoprotein B (-14.1%). The plasma cholesterol reduction was higher in patients with apolipoprotein E3/E3 or E3/E4 vs an almost negligible effect on E3/E2. These results confirm that soy-protein diets can lower cholesterol in type IIa patients with familial disease. Data on the sensitivity of patients with different apo-E isoforms agree with recent hypotheses suggesting that soy proteins may activate B,E receptors.





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