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Influence of morbidity on serum retinol of children in a community-based study in northern Ghana / SM Filteau; SS Morris; RA Abbott; et.al..-- pp.192-7.-- En: American Journal of Clinical Nutrition.-- 58, 2 (1993)
MORBILIDAD   VITAMINA A   DEFICIENCIA DE VITAMINA A   NIÑO   PROTEINAS
Categoría geográfica: GHANA  
Ubicación: Centro de Información y Documentación (CANIA)   
Solicite el material por este código: AS-0461
Tipo de Material:
Separata

    Serum retinol concentrations decrease during illness and thus may not accurately reflect the vitamin A status of populations with a high prevalence of illness. To quantify the contribution of illness to low serum retinol in a field study of children aged 6-59 mo in northern Ghana, serum retinol values were compared with two indicators of recent illness; symptoms reported by parents and acute-phase protein concentrations in serum. Serum retinol was not associated with symptoms of illness but showed a significant negative correlation with both alpha 1-acid glycoprotein (AGP) and serum amyloid A (SAA). Elevated AGP was associated with a 24% decrease in mean serum retinol. A large proportion of asymptomatic children had elevated AGP or SAA concentrations, suggesting that subclinical infections may have had important effects on serum retinol. A significant negative correlation between malaria parasite density and serum retinol indicated that malaria may have been one of the subclinical infections responsible. Measurement of AGP may improve interpretation of serum retinol data from populations with a high prevalence of morbidity.

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Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants / A Lucas; MS Fewtrell; R Morley; A Singhal; RA Abbott; E Isaacs; T Stephenson; UM MacFadyen; H Clements.-- pp. 703-711.-- En: Pediatrics.-- 108, 3 (2001)
Notas de Contenido:
Material no impreso
ANTROPOMETRIA   PUNTAJE DE APGAR   LACTANCIA MATERNA   CEFALOMETRIA   ESTUDIO COMPARATIVO   METODO DOBLE CIEGO   FEMENINO   HUMANO   LACTANTE   ALIMENTOS INFANTILES   RECIEN NACIDO   PREMATURO   MASCULINO   EVALUACION NUTRICIONAL   FACTORES SEXUALES   GROSOR DE PLIEGUES CUTANEOS
Ubicación: Centro de Información y Documentación (CANIA)   
Tipo de Material:
Separata

    OBJECTIVES: Preterm infants are frequently discharged from the hospital growth retarded and show reduced growth throughout childhood. In a large efficacy and safety trial, we tested the hypothesis that nutritional intervention in the first 9 months postterm would reverse postdischarge growth deficits and improve neurodevelopment without adverse safety outcomes. PARTICIPANTS AND INTERVENTION: Two hundred eighty-four infants (mean gestation: 30.9 weeks) were studied; 229 were randomly assigned a protein, energy, mineral, and micronutrient-enriched postdischarge formula (PDF; N = 113) or standard term formula (TF; N = 116) from discharge (mean 36.5 weeks' postmenstrual age). A reference group (N = 65) was breastfed until at least 6 weeks' postterm. Outcome measures. Anthropometry was performed at 6 weeks and 3, 6, 9, and 18 months. Development was measured at 9 months (Knobloch, Passamanick, and Sherrard's developmental screening inventory) and 18 months (Bayley Scales of Infant Development II; primary outcome) postterm. RESULTS: At 9 months, compared with the TF group, those fed PDF were heavier (difference 370 g; 95% confidence interval [CI]: 84-660) and longer (difference 1.1 cm; 95% CI: 0.3-1.9); the difference in length persisted at 18 months (difference 0.82 cm; 95% CI: -0.04-1.7). There was no effect on head circumference. The effect of diet was greatest in males; at 9 months length deficit with TF was 1.5cm (95% CI: 0.3-2.7), and this remained at 18 months (1.5cm [95% CI: 0.3-2.7]). There was no significant difference in developmental scores at 9 or 18 months, although PDF infants had a 2.8 (-1.3-6.8) point advantage in Bayley motor score scales. At 6 weeks' postterm, exclusively breastfed infants were already 513 g (95% CI: 310-715) lighter and 1.6cm (95% CI: 0.8-2.3) shorter than the PDF group, and they remained smaller up to 9 months' postterm. CONCLUSIONS: 1) Improving postdischarge nutrition in the first 9 months may reset subsequent growth-at least until 18 months for body length. We intend to follow-up the children at older ages. The observed efficacy of PDF was not associated with adverse safety outcomes. 2) We cannot reject the hypothesis that postdischarge nutrition benefits motor development and this requires additional study. 3) Our data raise the possibility that breastfed postdischarge preterm infants may require nutritional supplementation, currently under investigation.

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